AG Schmidt-Ott

Leitung:

Prof. Dr. Kai Schmidt-Ott

Mitarbeiterinnen und Mitarbeiter:

Felix Boivin, PhD, Wissenschaftlicher Mitarbeiter
(Postdoc-Stipendium der Alexander von Humboldt-Stiftung)

Dr. rer. nat. Katharina Walentin, Wissenschaftliche Mitarbeiterin

Dr. med. Christian Hinze, Wissenschaftlicher Mitarbeiter (Charité/BIH Clinician Scientist)

Janna Leiz, PhD-Studentin (Graduiertenkolleg 2318)

Zeliha Yesim Yurtdas, PhD-Studentin (Stiftung Urologische Forschung, MDC Transcard Research School)

Fatma A. A. Mansour, PhD-Studentin (Stipendium der Universität Kairo, Stiftung Urologische Forschung)

Sinisa Simonovic, PhD-Student (Stiftung Urologische Forschung)

Paula Halbeisen, Medizinische Doktorandin

Ricarda Merle Hinz, Medizinische Doktorandin

Alexander Holler, Medizinischer Doktorand (Graduiertenkolleg 2318)

Carolin Elfriede Markus, Medizinische Doktorandin

Jutta Swolinsky, Medizinische Doktorandin

Tatjana Luganskaja, Medizinisch-technische Laboratoriumsassistentin (MTLA)

Swolinsky JS, Nerger NP, Leistner DM, Edelmann F, Knebel F, Tuvshinbat E, Lemke C, Roehle R, Haase M, Costanzo MR, Rauch G, Mitrovic V, Gasanin E, Meier D, McCullough PA, Eckardt KU, Molitoris BA, Schmidt-Ott KM. Serum creatinine and cystatin C-based estimates of glomerular filtration rate are misleading in acute heart failure. ESC Heart Failure. 2021, in press.

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Hardenberg JHB, Stockmann H, Aigner A, Gotthardt I, Enghard P, Hinze C, Balzer F, Schmidt D, Zickler D, Kruse J, Körner R, Stegemann M, Schneider T, Schumann M, Müller-Redetzky H, Angermair S, Budde K, Weber-Carstens S, Witzenrath M, Treskatsch S, Siegmund B, Spies C, Suttorp N, Rauch G, Eckardt KU, Schmidt-Ott KM. Critical illness and systemic inflammation are key risk factors of severe AKI in patients with COVID-19. Kidney International Reports. 2021, 6: 905-915.

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Stockmann H, Hardenberg JB, Aigner A, Hinze C, Gotthardt I, Stier B, Eckardt KU, Schmidt-Ott KM*, Enghard P*. High rates of long-term renal recovery in survivors of COVID-19-associated acute kidney injury requiring kidney replacement therapy. Kidney International. 2021, 99: 1021–1022. *Corresponding authors.

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Hinze C, Karaiskos N, Boltengagen A, Walentin K, Redo K, Himmerkus N, Bleich M, Potter SS, Potter AS, Eckardt KU, Kocks C, Rajewsky N*, Schmidt-Ott KM*. Kidney Single-cell Transcriptomes Predict Spatial Corticomedullary Gene Expression and Tissue Osmolality Gradients. Journal of the American Society of Nephrology. 2021, 32: 291-306. *Corresponding authors.

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Khadzhynov D*, Schmidt D*, Hardt J, Rauch G, Gocke P, Eckardt KU, Schmidt-Ott KM. The incidence of acute kidney injury and associated hospital mortality—a retrospective cohort study of over 100 000 patients at Berlin‘s Charité hospital. Deutsches Ärzteblatt Int. 2019, 116: 397-404. *Co-first

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Vukićević T*, Hinze C*, Baltzer S, Himmerkus N, Quintanova C, Zühlke K, Compton F, Ahlborn R, Dema A, Eichhorst J, Wiesner B, Bleich M, Schmidt-Ott KM**, Klussmann E**. Fluconazole Increases Osmotic Water Transport in Renal Collecting Duct through Effects on Aquaporin-2 Trafficking. Journal of the American Society of Nephrology. 2019, 30: 795-810. *Co-first, **Corresponding authors.

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Vigolo E*, Marko L*, Hinze C, Müller DN**, Schmidt-Ullrich R**, Schmidt-Ott KM**. Canonical BMP signaling in tubular cells mediates recovery after acute kidney injury. Kidney International, 2019, 95:108-122. *Co-first, **Equally contributing principal investigators.

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Hinze C *, Ruffert J*, Walentin K*, Himmerkus N, Nikpey E, Tenstad O, Wiig H, Mutig K, Yurtdas ZY, Klein JD, Sands JM, Branchi F, Schumann M, Bachmann S, Bleich M, Schmidt-Ott KM. GRHL2 is required for collecting duct epithelial barrier function and renal osmoregulation. Journal of the American Society of Nephrology. 2018, 29: 857-868. *Co-first

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Ming Q, Roske Y, Schuetz A, Walentin K, Ibraimi I, Schmidt-Ott KM, Heinemann U. Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family. Nucleic Acids Research. 2018,46: 2082-2095.

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Werth M*, Schmidt-Ott KM*, Leete T, Qiu A, Hinze C, Viltard M, Paragas N, Shawber CJ, Yu W, Lee P, Chen X, Sarkar A, Mu W, Rittenberg A, Lin CS, Kitajewski J, Al-Awqati Q, Barasch J. Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts. Elife. 2017, 6. pii: e24265. *Co-first

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Marko L*, Vigolo E*, Hinze C, Park JK, Roel G, Balogh A, Choi M, Wuebken A, Cording J, Blasig IE, Luft FC, Scheidereit C, Schmidt-Ott KM**, Schmidt-Ullrich R**, Muller DN**. Tubular Epithelial NF-kB Activity Regulates Ischemic AKI. Journal of the American Society of Nephrology. 2016, 27:2658-69. *Co-first, **Equally contributing principal investigators.

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Aue A*, Hinze C*, Walentin K, Ruffert J, Yurtdas ZY, Werth M, Chen W, Rabien A, Kilic E, Schulzke JD, Schumann M, Schmidt-Ott KM. A grainyhead-like 2/ovo-like 2 pathway regulates renal epithelial barrier function and lumen expansion. Journal of the American Society of Nephrology. 2015, 26:2704-15.* Equal contribution.

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Walentin K, Hinze C, Werth M, Haase N, Varma S, Morell R, Aue A, Pötschke E, Warburton D, Qiu A, Barasch J, Purfürst B, Dieterich C, Popova E, Bader M, Dechend R, Staff AC, Yurtdas ZY, Kilic E, Schmidt-Ott KM. A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Development. 2015, 142:1125-36.

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Paragas N*, Kulkarni R*, Werth M*, Schmidt-Ott KM*, Forster C, Deng R, Zhang Q, Singer E, Klose AD, Shen TH, Francis KP, Ray S, Vijayakumar S, Seward S, Bovino ME, Xu K, Takabe Y, Amaral FE, Mohan S, Wax R, Corbin K, Sanna-Cherchi S, Mori K, Johnson L, Nickolas T, D'Agati V, Lin CS, Qiu A, Al-Awqati Q, Ratner AJ, Barasch J. α-Intercalated cells defend the urinary system from bacterial infection. Journal of Clinical Investigation. 2014, 124:2963-76. *Equal contribution.

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Nickolas TL*#, Schmidt-Ott KM*#, Canetta P, Forster C, Singer E, Sise M, Elger A, Maarouf O, Sola-Del Valle DA, O’Rourke M, Sherman E, Lee P, Geara A, Imus P, Guddati A, Polland A, Rahman W, Elitok S, Malik N, Giglio J, El-Sayegh S, Devarajan P, Hebbar S, Saggi SJ, Hahn B, Kettritz R, Luft FC, Barasch J. Diagnostic and Prognostic Stratification in the Emergency Department Using Urinary Biomarkers of Nephron Damage - A Multicenter Prospective Cohort Study. Journal of the American College of Cardiology. 2012, 59:235-44. *Equal contribution. #Corresponding authors.

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Singer E, Elger A, Elitok S, Kettritz R, Nickolas TL, Barasch J, Luft FC, Schmidt-Ott KM. Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes. Kidney International.2011, 80:405-14.

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Paragas N, Qiu A, Zhang Q, Samstein B, Deng SX, Schmidt-Ott KM, Viltard M, Yu W, Forster CS, Gong G, Liu Y, Kulkarni R, Mori K, Kalandadze A, Ratner AJ, Devarajan P, Landry DW, D'Agati V, Lin CS, Barasch J. The Ngal reporter mouse detects the response of the kidney to injury in real time. Nature Medicine. 2011, 17:216-22.

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Werth, M.*, Walentin, K.*, Aue, A., Schonheit, J., Wuebken, A., Pode-Shakked, N., Vilianovitch, L., Erdmann, B., Dekel, B., Bader, M., Barasch, J., Rosenbauser, F., Luft, F.C., Schmidt-Ott, K.M. 2010. The transcription factor grainyhead-like 2 (Grhl2) regulates the molecular composition of the epithelial apical junctional complex. Development. 2010, 137:3835-45. *Equal contribution.

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Bao G, Clifton M, Hoette TM, Mori K, Deng SX, Qiu A, Viltard M, Williams D, Paragas N, Leete T, Kulkarni R, Li X, Lee B, Kalandadze A, Ratner AJ, Pizarro JC, Schmidt-Ott KM, Landry DW, Raymond KN, Strong RK, Barasch J. Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. Nature Chemical Biology. 2010, 6(8):602-609.

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Li JY, Paragas N, Ned RM, Qiu A, Viltard M, Leete T, Drexler IR, Chen X, Sanna-Cherchi S, Mohammed F, Williams D, Lin CS, Schmidt-Ott KM, Andrews NC, Barasch J. Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Developmental Cell. 2009, 16:35-46.

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Lu BC, Cebrian C, Chi X, Kuure S, Kuo R, Bates CM, Arber S, Hassell J, Macneil L, Hoshi M, Jain S, Asai N, Takahashi M, Schmidt-Ott KM, Barasch J, D'Agati V, Costantini F. Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nature Genetics. 2009, 41:1295-1302.

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Schmidt-Ott KM, Masckauchan TN, Chen X, Hirsh BJ, Sarkar A, Yang J, Paragas N, Wallace VA, Dufort D, Pavlidis P, Jagla B, Kitajewski J, Barasch J. β-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors. Development. 2007, 134:3177-90.

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Schmidt-Ott KM, Yang J, Chen X, Wang H, Paragas N, Mori K, Li JY, Schiffer M, Bottinger E, Barasch J. Novel Regulators Of Kidney Development From The Tips Of The Ureteric Bud. Journal of the American Society of Nephrology. 2005, 16:1993-2002.

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Mori K, Lee HT, Rapoport D, Drexler IR, Foster K, Yang J, Schmidt-Ott KM, Chen X, Li JY, Weiss S, Mishra J, Cheema FH, Markowitz G, Suganami T, Sawai K, Mukoyama M, Kunis C, D´Agati V, Devarajan P, Barasch J. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. Journal of Clinical Investigation. 2005, 115:610-21.

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Zheng Z, Schmidt-Ott KM, Chua S, Foster KA, Frankel RZ, Pavlidis P, Barasch J, D´Agati VD, Gharavi AG. A Mendelian Locus on Chromosome 16 Determines Susceptibility to Doxorubicin Nephropathy In The Mouse. Proceedings of the National Academy of Sciences of the United States of America. 2005, 102:2502-7.

Deutsche Forschungsgemeinschaft:

DNA recognition-element binding by GRHL/CP2-family and NKX2-1 transcription factors (Forschergruppe 2841; seit 2019)

Targeting collecting duct barrier function for renoprotection (Sonderforschungsbereich 1365; seit 2019)

Transcriptional integration of tight junction assembly in renal epithelial cells (Graduiertenkolleg 2318; seit 2017)

Molecular physiology and epigenetics of NF-κB/BMP interactions in the post-ischemic kidney (Forschergruppe 1368; 2014-2018)

Therapeutic implications and pathophysiological role of calprotectin in acute kidney injury (Forschergruppe 1368; 2014-2018)

NF-κB and BMP signaling in acute renal injury (Forschergruppe 1368;2011-2013)

The role of the transcription factor grainyhead-like 2 (Grhl2) in transcriptional regulation of apical junctional complex components in collecting duct epithelia of the kidney (Forschergruppe 667; 2009-2013)

The role of ß-Catenin/TCF-dependent transcriptional networks in morphogenesis and regeneration of renal epithelia (Emmy Noether Program Research Group; 2007-2013)

Unsere Arbeitsgruppe wird unterstützt von der Stiftung Urologische Forschung (Link: stiftung-urologie.de)

Auswahl:

Prof. Jonathan Barasch, Columbia University, New York

Prof. Markus Bleich, Universität Kiel

Prof. Dominik N. Müller, Max Delbrück Centrum für Molekulare Medizin

Prof. Nikolaus Rajewsky, Max Delbrück Centrum für Molekulare Medizin

Prof. Timm Westhoff, Marienhospital Herne