AG Schmidt-Ott

Molekulare und Translationale Nierenforschung / Molecular and Translational Kidney Research

Leiter:

Prof. Dr. med. Kai M. Schmidt-Ott

Link zur Arbeitsgruppenhomepage am MDC:

https://www.mdc-berlin.de/schmidt-ott

Sie befinden sich hier:

Forschungsschwerpunkte

  • Genregulatorische Netzwerke der renalen Embryonalentwicklung und Homöostase
  • Mechanismen der akuten Nierenschädigung und Regeneration
  • Molekulare Diagnostik von Nierenerkrankungen

Mitarbeiterinnen und Mitarbeiter der Arbeitsgruppe

Leitung:

Prof. Dr. Kai Schmidt-Ott

Mitarbeiterinnen und Mitarbeiter:

Dr. rer. nat. Katharina Walentin, Wissenschaftliche Mitarbeiterin

Dr. med. Christian Hinze, Wissenschaftlicher Mitarbeiter

Dr. med. Eva Schrezenmeier, Wissenschaftliche Mitarbeiterin (Charité/BIH Junior Clinical Scientist)

Janett Ruffert, PhD-Studentin (Stiftung Urologische Forschung, MDC Transcard Research School)

Emilia Vigolo, PhD-Studentin (MDC Transcard Research School)

Zeliha Yesim Yurtdas, PhD-Studentin (Stiftung Urologische Forschung, MDC Transcard Research School)

Fatma A. A. Mansour, PhD-Studentin (Stipendium der Universität Kairo)

Ricarda Merle Viol, Medizinische Doktorandin

Carolin Elfriede Markus, Medizinische Doktorandin

Jutta Swolinsky, Medizinische Doktorandin

Paula Halbeisen, Medizinische Doktorandin

Tatjana Luganskaja, Medizinisch-technische Laboratoriumsassistentin (MTLA)

Gabriel Kirchgraber, Medizinisch-technischer Laboratoriumsassistent (MTLA)

Ausgewählte Publikationen

Werth M*, Schmidt-Ott KM*, Leete T, Qiu A, Hinze C, Viltard M, Paragas N, Shawber CJ, Yu W, Lee P, Chen X, Sarkar A, Mu W, Rittenberg A, Lin CS, Kitajewski J, Al-Awqati Q, Barasch J. Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts. Elife. 2017, in press. *Co-first

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Marko L*, Vigolo E*, Hinze C, Park JK, Roel G, Balogh A, Choi M, Wuebken A, Cording J, Blasig IE, Luft FC, Scheidereit C, Schmidt-Ott KM**, Schmidt-Ullrich R**, Muller DN**. Tubular Epithelial NF-kB Activity Regulates Ischemic AKI. Journal of the American Society of Nephrology. 2016, 27:2658-69. *Co-first, **Equally contributing principal investigators.

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Aue A*, Hinze C*, Walentin K, Ruffert J, Yurtdas ZY, Werth M, Chen W, Rabien A, Kilic E, Schulzke JD, Schumann M, Schmidt-Ott KM. A grainyhead-like 2/ovo-like 2 pathway regulates renal epithelial barrier function and lumen expansion. Journal of the American Society of Nephrology. 2015, 26:2704-15.* Equal contribution.

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Walentin K, Hinze C, Werth M, Haase N, Varma S, Morell R, Aue A, Pötschke E, Warburton D, Qiu A, Barasch J, Purfürst B, Dieterich C, Popova E, Bader M, Dechend R, Staff AC, Yurtdas ZY, Kilic E, Schmidt-Ott KM. A Grhl2-dependent gene network controls trophoblast branching morphogenesis. Development. 2015, 142:1125-36.

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Paragas N*, Kulkarni R*, Werth M*, Schmidt-Ott KM*, Forster C, Deng R, Zhang Q, Singer E, Klose AD, Shen TH, Francis KP, Ray S, Vijayakumar S, Seward S, Bovino ME, Xu K, Takabe Y, Amaral FE, Mohan S, Wax R, Corbin K, Sanna-Cherchi S, Mori K, Johnson L, Nickolas T, D'Agati V, Lin CS, Qiu A, Al-Awqati Q, Ratner AJ, Barasch J. α-Intercalated cells defend the urinary system from bacterial infection. Journal of Clinical Investigation. 2014, 124:2963-76. *Equal contribution.

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Nickolas TL*#, Schmidt-Ott KM*#, Canetta P, Forster C, Singer E, Sise M, Elger A, Maarouf O, Sola-Del Valle DA, O’Rourke M, Sherman E, Lee P, Geara A, Imus P, Guddati A, Polland A, Rahman W, Elitok S, Malik N, Giglio J, El-Sayegh S, Devarajan P, Hebbar S, Saggi SJ, Hahn B, Kettritz R, Luft FC, Barasch J. Diagnostic and Prognostic Stratification in the Emergency Department Using Urinary Biomarkers of Nephron Damage - A Multicenter Prospective Cohort Study. Journal of the American College of Cardiology. 2012, 59:235-44. *Equal contribution. #Corresponding authors.

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Singer E, Elger A, Elitok S, Kettritz R, Nickolas TL, Barasch J, Luft FC, Schmidt-Ott KM. Urinary neutrophil gelatinase-associated lipocalin distinguishes pre-renal from intrinsic renal failure and predicts outcomes. Kidney International.2011, 80:405-14.

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Paragas N, Qiu A, Zhang Q, Samstein B, Deng SX, Schmidt-Ott KM, Viltard M, Yu W, Forster CS, Gong G, Liu Y, Kulkarni R, Mori K, Kalandadze A, Ratner AJ, Devarajan P, Landry DW, D'Agati V, Lin CS, Barasch J. The Ngal reporter mouse detects the response of the kidney to injury in real time. Nature Medicine. 2011, 17:216-22.

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Werth, M.*, Walentin, K.*, Aue, A., Schonheit, J., Wuebken, A., Pode-Shakked, N., Vilianovitch, L., Erdmann, B., Dekel, B., Bader, M., Barasch, J., Rosenbauser, F., Luft, F.C., Schmidt-Ott, K.M. 2010. The transcription factor grainyhead-like 2 (Grhl2) regulates the molecular composition of the epithelial apical junctional complex. Development. 2010, 137:3835-45. *Equal contribution.

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Bao G, Clifton M, Hoette TM, Mori K, Deng SX, Qiu A, Viltard M, Williams D, Paragas N, Leete T, Kulkarni R, Li X, Lee B, Kalandadze A, Ratner AJ, Pizarro JC, Schmidt-Ott KM, Landry DW, Raymond KN, Strong RK, Barasch J. Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. Nature Chemical Biology. 2010, 6(8):602-609.

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Li JY, Paragas N, Ned RM, Qiu A, Viltard M, Leete T, Drexler IR, Chen X, Sanna-Cherchi S, Mohammed F, Williams D, Lin CS, Schmidt-Ott KM, Andrews NC, Barasch J. Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Developmental Cell. 2009, 16:35-46.

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Lu BC, Cebrian C, Chi X, Kuure S, Kuo R, Bates CM, Arber S, Hassell J, Macneil L, Hoshi M, Jain S, Asai N, Takahashi M, Schmidt-Ott KM, Barasch J, D'Agati V, Costantini F. Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nature Genetics. 2009, 41:1295-1302.

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Schmidt-Ott KM, Masckauchan TN, Chen X, Hirsh BJ, Sarkar A, Yang J, Paragas N, Wallace VA, Dufort D, Pavlidis P, Jagla B, Kitajewski J, Barasch J. β-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors. Development. 2007, 134:3177-90.

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Schmidt-Ott KM, Yang J, Chen X, Wang H, Paragas N, Mori K, Li JY, Schiffer M, Bottinger E, Barasch J. Novel Regulators Of Kidney Development From The Tips Of The Ureteric Bud. Journal of the American Society of Nephrology. 2005, 16:1993-2002.

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Mori K, Lee HT, Rapoport D, Drexler IR, Foster K, Yang J, Schmidt-Ott KM, Chen X, Li JY, Weiss S, Mishra J, Cheema FH, Markowitz G, Suganami T, Sawai K, Mukoyama M, Kunis C, D´Agati V, Devarajan P, Barasch J. Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. Journal of Clinical Investigation. 2005, 115:610-21.

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Zheng Z, Schmidt-Ott KM, Chua S, Foster KA, Frankel RZ, Pavlidis P, Barasch J, D´Agati VD, Gharavi AG. A Mendelian Locus on Chromosome 16 Determines Susceptibility to Doxorubicin Nephropathy In The Mouse. Proceedings of the National Academy of Sciences of the United States of America. 2005, 102:2502-7.

 

 

Öffentliche Projektförderungen der letzten 5 Jahre

Deutsche Forschungsgemeinschaft:

Transcriptional integration of tight junction assembly in renal epithelial cells (Graduiertenkolleg 2318; seit 2017)

Molecular physiology and epigenetics of NF-κB/BMP interactions in the post-ischemic kidney (FOR 1368; seit 2014)

Therapeutic implications and pathophysiological role of calprotectin in acute kidney injury (FOR 1368;seit 2014)

NF-κB and BMP signaling in acute renal injury (FOR 1368;2011-2013)

The role of the transcription factor grainyhead-like 2 (Grhl2) in transcriptional regulation of apical junctional complex components in collecting duct epithelia of the kidney (FOR667; 2009-2013)

The role of ß-Catenin/TCF-dependent transcriptional networks in morphogenesis and regeneration of renal epithelia (Emmy Noether Program Research Group; 2007-2013)

Unsere Arbeitsgruppe wird unterstützt von der Stiftung Urologische Forschung (Link: stiftung-urologie.de)

Kooperationen

Auswahl:

Prof. Jonathan Barasch, Columbia University, New York

Prof. Markus Bleich, Universität Kiel

Prof. Dominik N. Müller, Max Delbrück Centrum für Molekulare Medizin

Prof. Nikolaus Rajewsky, Max Delbrück Centrum für Molekulare Medizin

Prof. Timm Westhoff, Marienhospital Herne